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Cellartis®iPSC CRISPR/Cas9 Gesicle和单细胞克隆系统

1系统

许可声明

身份证号码
396	本产品及其使用是下列一项或多项已颁发专利和专利申请的主题:澳大利亚专利号2013355214;2017204031;和2018229489;加拿大专利号2,891,347和2,977,152;中国专利号CN105142669;欧洲专利号EP 2 928 496 B1;Ep 3 138910 b1, 3 138911 b1, Ep 3 138912 b1, Ep 3 360 964 b1, Ep 3 363 902 b1;以色列没有申请专利。IL238856; Singapore Patent No. 11201503824S; South Korea Patent Nos. 10-1844123 and 10-2006880; and U.S. Patent Application Serial Nos. 15/188,911; 15/188,924; 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”). The purchase of this Product conveys to you (the “Buyer”) the NON-TRANSFERABLE right to use the Product for Licensed Research Use (see definition below) subject to the conditions set out in this License Agreement. 1. “Licensed Research Use” means any use for research purposes, except: (i) Buyer may not sell or otherwise transfer the Product (including without limitation any material that contains the Product in whole or part) or any Related Material to any other third party (except that you may transfer the Product, or any Related Material to a bona fide collaborator or contract research organization), or use the Products or any Related Material to perform services for the benefit of any other third party; (ii) Buyer may use only the purchased amount of the Product and components of the Product, and shall use any Related Material, only for your internal research within the Field, and not for any Commercial Purposes; (iii) Buyer shall use the Product and any Related Material in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations; and (iv) the Buyer shall indemnify, defend, and hold harmless SIGMA and their current and former directors, officers, employees and agents, and their respective successors, heirs and assigns (the “Indemnities”) against any liability, damage, loss, or expense (including without limitation reasonable attorneys’ fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer hereunder or any breach of this License Agreement by such Buyer. 2. For purposes of Section 1 above, the following definitions shall apply: “Commercial Purposes” means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration, or on any other commercial basis. “Field” means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any in vivo and ex vivo human or clinical use, including, without limitation, any administration into humans or any diagnostic or prognostic use, (b) the creation of transgenic rodent models and/or derivatives thereof (including, but not limited to, rodents’ cells and rodents’ organs) by for-profit entities, (c) any in vivo veterinary or livestock use, or non-research agricultural use, or (d) use as a testing service, therapeutic or diagnostic for humans or animals. “Related Materials” means any progeny, modification or derivative of a Product. 3. Your right to use the Product will terminate immediately if you fail to comply with these terms and conditions. You shall, upon such termination of your rights, destroy all Product, Related Materials, and components thereof in your control, and notify SIGMA of such in writing. For information on purchasing a license to this Product for purposes other than Licensed Research Use, contact your local SIGMA sales representative, or call +1 800-325-3010.
C001	本产品由Takara Bio Europe AB基于威斯康星州校友研究基金会(“WARF”)持有的某些知识产权的商业许可生产和销售。本产品受美国专利No. 7,514,260及其国外同类产品的一项或多项权利要求的保护。本产品的购买向买方传递了不可转让的权利，即按照其预期用途使用本产品，严格限于买方自己的内部研究。买方未获得任何其他明示或默示许可。买方无权为任何目的(包括但不限于诊断和/或治疗，或其他临床试验)在人体中使用本产品或其成分。购买不包括任何转售或转让本产品给第三方的权利，无论是否收到赔偿。希望将本产品用于内部研究用途以外的目的的购买者应与我们联系。
391	有限用途标签许可:仅用于研究该产品的许可证授予美国豆类生物从驯鹿生物科学公司及其子公司,Inc .)和本产品转移到终端用户购万博体育投注manbetx登录买者(“买方”)受到“有限使用标签许可证”输送买方有限,使用产品不可转让的权利,仅仅提供给买家,与(i)买方产生的产品的子代或衍生物(包括但不限于细胞)，以及(ii)从产品或其相应子代或衍生物(包括但不限于细胞)中提取或衍生的生物材料(统称为产品，以及(i)和(ii)被称为“材料”)仅用于为买方的唯一利益进行内部研究。买方不得出售或以其他方式转让材料给第三方，或以其他方式将材料用于任何除外用途。“除外用途”指任何及所有:(a)商业活动，包括但不限于生产(包括但不限于用于生物生产的细胞系开发)、产品检测或质量控制的任何用途;(b)临床前或临床试验或其他旨在向美国食品和药物管理局或任何其他国家或司法管辖区的监管机构提交数据的活动，该等研究中的活性制剂包含该材料;(c)用于向第三方提供服务、信息或数据;(d)用于人类或动物治疗、诊断或预防的用途，或作为治疗、诊断或预防的产品;(e)农业田间试验活动或向美国农业部或任何其他农业监管机构提交数据的任何活动; (f) high throughput screening drug discovery purposes (i.e., the screening of more than 10,000 experiments per day) as well as scale-up production activities for commercialization; (g) modification of human germline, including editing of human embryo genomes (with the sole exception of editing human embryonic stem (ES) cell lines for research purposes) or reproductive cells; (h) self-editing; and/or (i) stimulation of biased inheritance of a particular gene or trait or set of genes or traits (“gene drive”). It is the Purchaser’s responsibility to use the Material in accordance with all applicable laws and regulations. For information on obtaining additional rights, including commercial rights, please contact licensing@cariboubio.com or Caribou Biosciences, Inc., 2929 7th Street, Suite 105, Berkeley, CA 94710 USA, Attn: Licensing.
405	本产品受美国专利9593356和10793828及相应的国外专利保护。其他专利正在申请中。欲了解更多授权信息，请通过电子邮件联系Takara Bio USA授权代表licensing@takarabio.com。
72	活彩荧光蛋白产品: 非营利性实体:可以通过与您的当地代表或Takara Bio USA, Inc.联系的正常方式下订单。万博体育投注manbetx登录客户服务。本产品的任何和所有使用将受非商业使用许可协议(“非商业许可”)的条款和条件的约束，该协议的副本可在下面找到。作为向您销售本产品的条件，在使用本产品之前，您必须同意非商业许可的条款和条件。根据非商业性许可，Takara Bio USA, Inc.授予非营利万博体育投注manbetx登录性实体非排他的、不可转让的、不可再许可的和有限的许可，仅将本产品用于内部的、非商业性的科学研究用途。该等许可明确排除了向第三方出售或以其他方式转让本产品、其组件或其衍生品的权利。未经Takara Bio USA, Inc.的明确书面许可，不得对产品进行任何修改。万博体育投注manbetx登录本产品的任何其他用途需要Takara Bio USA, Inc.的不同许可证。万博体育投注manbetx登录有关许可信息，请通过电话650.919.7320或电子邮件licensing@takarabio.com与许可代表联系。希望使用本产品的营利性实体需要从Takara Bio USA, Inc.获得许可。万博体育投注manbetx登录有关许可信息，请通过电话650.919.7320或电子邮件licensing@takarabio.com与许可代表联系。非营利性非商业性使用许可: Cellartis®iPSC CRISPR/Cas9 Gesicle和单细胞克隆系统产品许可协议的副本可以点击这里找到。
44	dsred -单体和水果荧光蛋白由下列一项或多项美国专利覆盖:7,005,511和7,393,923。
63	本产品的使用包括以下一个或多个美国专利号和相应的美国以外的专利要求:6,998,115;7427394年。本产品仅用于研究目的。不得用于(i)任何人类或兽医用途，包括但不限于治疗和预防用途，(ii)任何临床用途，包括但不限于诊断用途，(iii)筛选化学和/或生物化合物以鉴定药物活性制剂(包括但不限于小分子筛选)、目标验证、临床前测试服务或药物开发。在上述任何用途上使用本产品都需要获得麻省理工学院的许可。
272	本产品(“产品”)及其使用是美国专利8,697,359和8,771,945的主体，并正在申请美国专利。购买产品传达给买方不可转让的使用权(s)从豆类生物购买美国产品,公司或其附属公司,以及任何后代,修改或衍生品的产品,或通过使用或修改的任何细胞或动物的产品,或任何后代,万博体育投注manbetx登录该细胞或动物的修饰或衍生物(“相关材料”)，仅用于买方按照以下所有要求进行的研究。没有权利将本产品或相关材料用于任何其他目的，包括但不限于用于药物、体外诊断目的、治疗或人体。买方不得出售或转让产品(包括但不限于任何材料,包含全部或部分的许可产品)或任何相关材料到任何其他个人或实体,或使用的产品或任何相关材料来执行服务,造福其他任何个人或实体,(2)买方应只使用购买的产品的产品和组件,并使用任何相关材料,仅为其内部研究和不是(a),性能或提供任何方法、过程或服务,或(b)制造、销售、使用、分配、性格或进口任何产品,在每种情况下(a)或(b)出于考虑，或基于任何其他商业基础(“商业目的”)，(iii)买方应遵守所有适用法律和法规，包括但不限于适用的人类健康和动物福利法律和法规，使用许可产品和任何相关材料，以及(iv)买方应就MIT、Harvard和the Broad及其现任和前任受托人、董事、官员、教职员工、附属调查人员、学生、雇员和代理人及其各自的继承人、继承人和受让人(“受赔偿人”)的任何责任、损害、损失、或因行使授予买方的任何权利而产生的或与之相关的任何索赔、诉讼、调查、诉讼、要求或判决而由任何受赔偿方产生或强加于任何受赔偿方的费用(包括但不限于合理的律师费和开支)，或违反买方在本协议项下授予的任何权利。
325	专利申请中。欲了解更多信息，请通过电子邮件联系Takara Bio USA授权代表licensing@takarabio.com。

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Cellartis®iPSC CRISPR/Cas9 Gesicle和单细胞克隆系统

Cellartis®iPSC rCas9电穿孔和单细胞克隆系统

1系统

许可声明

身份证号码
396	本产品及其使用是下列一项或多项已颁发专利和专利申请的主题:澳大利亚专利号2013355214;2017204031;和2018229489;加拿大专利号2,891,347和2,977,152;中国专利号CN105142669;欧洲专利号EP 2 928 496 B1;Ep 3 138910 b1, 3 138911 b1, Ep 3 138912 b1, Ep 3 360 964 b1, Ep 3 363 902 b1;以色列没有申请专利。IL238856; Singapore Patent No. 11201503824S; South Korea Patent Nos. 10-1844123 and 10-2006880; and U.S. Patent Application Serial Nos. 15/188,911; 15/188,924; 15/188,927; 15/188,931; and 15/456,204 (the “Patent Rights”). The purchase of this Product conveys to you (the “Buyer”) the NON-TRANSFERABLE right to use the Product for Licensed Research Use (see definition below) subject to the conditions set out in this License Agreement. 1. “Licensed Research Use” means any use for research purposes, except: (i) Buyer may not sell or otherwise transfer the Product (including without limitation any material that contains the Product in whole or part) or any Related Material to any other third party (except that you may transfer the Product, or any Related Material to a bona fide collaborator or contract research organization), or use the Products or any Related Material to perform services for the benefit of any other third party; (ii) Buyer may use only the purchased amount of the Product and components of the Product, and shall use any Related Material, only for your internal research within the Field, and not for any Commercial Purposes; (iii) Buyer shall use the Product and any Related Material in compliance with all applicable laws and regulations, including without limitation applicable human health and animal welfare laws and regulations; and (iv) the Buyer shall indemnify, defend, and hold harmless SIGMA and their current and former directors, officers, employees and agents, and their respective successors, heirs and assigns (the “Indemnities”) against any liability, damage, loss, or expense (including without limitation reasonable attorneys’ fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, investigations, actions, demands or judgments arising out of or related to the exercise of any rights granted to the Buyer hereunder or any breach of this License Agreement by such Buyer. 2. For purposes of Section 1 above, the following definitions shall apply: “Commercial Purposes” means (a) the practice, performance or provision of any method, process or service, or (b) the manufacture, sale, use, distribution, disposition or importing of any product, in each case (a) or (b) for consideration, or on any other commercial basis. “Field” means use as a research tool for research purposes; provided, however, that notwithstanding the foregoing, the Field shall expressly exclude (a) any in vivo and ex vivo human or clinical use, including, without limitation, any administration into humans or any diagnostic or prognostic use, (b) the creation of transgenic rodent models and/or derivatives thereof (including, but not limited to, rodents’ cells and rodents’ organs) by for-profit entities, (c) any in vivo veterinary or livestock use, or non-research agricultural use, or (d) use as a testing service, therapeutic or diagnostic for humans or animals. “Related Materials” means any progeny, modification or derivative of a Product. 3. Your right to use the Product will terminate immediately if you fail to comply with these terms and conditions. You shall, upon such termination of your rights, destroy all Product, Related Materials, and components thereof in your control, and notify SIGMA of such in writing. For information on purchasing a license to this Product for purposes other than Licensed Research Use, contact your local SIGMA sales representative, or call +1 800-325-3010.
C001	本产品由Takara Bio Europe AB基于威斯康星州校友研究基金会(“WARF”)持有的某些知识产权的商业许可生产和销售。本产品受美国专利No. 7,514,260及其国外同类产品的一项或多项权利要求的保护。本产品的购买向买方传递了不可转让的权利，即按照其预期用途使用本产品，严格限于买方自己的内部研究。买方未获得任何其他明示或默示许可。买方无权为任何目的(包括但不限于诊断和/或治疗，或其他临床试验)在人体中使用本产品或其成分。购买不包括任何转售或转让本产品给第三方的权利，无论是否收到赔偿。希望将本产品用于内部研究用途以外的目的的购买者应与我们联系。
391	有限用途标签许可:仅用于研究该产品的许可证授予美国豆类生物从驯鹿生物科学公司及其子公司,Inc .)和本产品转移到终端用户购万博体育投注manbetx登录买者(“买方”)受到“有限使用标签许可证”输送买方有限,使用产品不可转让的权利,仅仅提供给买家,与(i)买方产生的产品的子代或衍生物(包括但不限于细胞)，以及(ii)从产品或其相应子代或衍生物(包括但不限于细胞)中提取或衍生的生物材料(统称为产品，以及(i)和(ii)被称为“材料”)仅用于为买方的唯一利益进行内部研究。买方不得出售或以其他方式转让材料给第三方，或以其他方式将材料用于任何除外用途。“除外用途”指任何及所有:(a)商业活动，包括但不限于生产(包括但不限于用于生物生产的细胞系开发)、产品检测或质量控制的任何用途;(b)临床前或临床试验或其他旨在向美国食品和药物管理局或任何其他国家或司法管辖区的监管机构提交数据的活动，该等研究中的活性制剂包含该材料;(c)用于向第三方提供服务、信息或数据;(d)用于人类或动物治疗、诊断或预防的用途，或作为治疗、诊断或预防的产品;(e)农业田间试验活动或向美国农业部或任何其他农业监管机构提交数据的任何活动; (f) high throughput screening drug discovery purposes (i.e., the screening of more than 10,000 experiments per day) as well as scale-up production activities for commercialization; (g) modification of human germline, including editing of human embryo genomes (with the sole exception of editing human embryonic stem (ES) cell lines for research purposes) or reproductive cells; (h) self-editing; and/or (i) stimulation of biased inheritance of a particular gene or trait or set of genes or traits (“gene drive”). It is the Purchaser’s responsibility to use the Material in accordance with all applicable laws and regulations. For information on obtaining additional rights, including commercial rights, please contact licensing@cariboubio.com or Caribou Biosciences, Inc., 2929 7th Street, Suite 105, Berkeley, CA 94710 USA, Attn: Licensing.
M54	本产品受美国专利7,704,713号及其国外同类产品的权利要求。
272	本产品(“产品”)及其使用是美国专利8,697,359和8,771,945的主体，并正在申请美国专利。购买产品传达给买方不可转让的使用权(s)从豆类生物购买美国产品,公司或其附属公司,以及任何后代,修改或衍生品的产品,或通过使用或修改的任何细胞或动物的产品,或任何后代,万博体育投注manbetx登录该细胞或动物的修饰或衍生物(“相关材料”)，仅用于买方按照以下所有要求进行的研究。没有权利将本产品或相关材料用于任何其他目的，包括但不限于用于药物、体外诊断目的、治疗或人体。买方不得出售或转让产品(包括但不限于任何材料,包含全部或部分的许可产品)或任何相关材料到任何其他个人或实体,或使用的产品或任何相关材料来执行服务,造福其他任何个人或实体,(2)买方应只使用购买的产品的产品和组件,并使用任何相关材料,仅为其内部研究和不是(a),性能或提供任何方法、过程或服务,或(b)制造、销售、使用、分配、性格或进口任何产品,在每种情况下(a)或(b)出于考虑，或基于任何其他商业基础(“商业目的”)，(iii)买方应遵守所有适用法律和法规，包括但不限于适用的人类健康和动物福利法律和法规，使用许可产品和任何相关材料，以及(iv)买方应就MIT、Harvard和the Broad及其现任和前任受托人、董事、官员、教职员工、附属调查人员、学生、雇员和代理人及其各自的继承人、继承人和受让人(“受赔偿人”)的任何责任、损害、损失、或因行使授予买方的任何权利而产生的或与之相关的任何索赔、诉讼、调查、诉讼、要求或判决而由任何受赔偿方产生或强加于任何受赔偿方的费用(包括但不限于合理的律师费和开支)，或违反买方在本协议项下授予的任何权利。

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Cellartis®iPSC rCas9电穿孔和单细胞克隆系统